Nanobiotics Formulations as Promising Advances for Combating Multidrug-Resistant Pathogenic MicrobesDr. Gharieb S. El-SayyadAbstract:After more than 100 years, Staphylococcus aureus (S. aureus) remains a significant harmful bacterial pathogen for humans. Both society and hospital-acquired staphylococcal diseases have exponentially grown. Due to the elevating antibiotic resistance and the lethal effect of multidrug-resistant strains, efficacious therapies for staphylococcal disorders are becoming increasingly restricted. Infections induced by resistant pathogens upgrade to high morbidity and mortality accelerations, leading to global healthcare costs. Drug-resistant bacterial infections donate to raised doses of medications, a mixture of drugs that promotes cell toxicity, prolonged hospitalization, and expanded mortality. Therefore, different therapy techniques have evolved into a critical condition. However, nanoparticles (NPs) are one of the most profitable strategies to attack microbial resistance. Antimicrobial NPs furnish numerous unique features corresponding to standard antibiotics in underestimating toxic influences, overpowering resistance, and reducing costs. There are even multiple nano-sized drugs presented for the efficient management of antibiotics by improving their pharmacokinetic parameters and minimizing the side outcomes. Formulations of the antibiotics as nano-drug and Nanobiotics could improve the susceptibility of pathogenic microbes to these antibiotics by reducing the minimum inhibitory concentration (MIC) values corresponding to their traditional ones. Therefore, this result can affect the pharmacodynamic parameters of the antibiotic and may have beneficial effects on the dosage regimen of nanobiotics as well as on the clinical results. |
Dr. Gharieb S. El-Sayyad, Ph.D. working as Lecturer of Medical Microbiology and Nanotechnology at Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. As Lecturer at Microbiology and Immunology Department, Faculty of Pharmacy, Galala University, Suez, Egypt.
He obtained his Bachelor of Science (B. Sc.) degree in Microbiology and Chemistry from Al-Azhar University, Cairo, Egypt with Excellent honor in June 2009. He obtained his Ph.D. (Medical Microbiology) from Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt in July 2017.
He has published more than 90 articles in high impacted international peer-reviewed journals with H-index 26, total citation 1883, and has presented his research work in the national and international workshops and conferences in Nano-biotechnology, Microbiology, Radiation Research, and Technology and Biomedical application of nanomaterials.
El-Sayyad’s research focuses on Green synthesis and characterization of nanocomposites, Microbial fermentation and Biotechnology, Microbial product and pigment, Biological control, Microbial resistance, nano-drug and Antimicrobial and anti-biofilm activities of the synthesized nano-materials against multi-drug resistant pathogenic microbes. Additionally, his research is focusing on the synthesis of new nanocomposites for decreasing the invasion of pathogenic microbes in biomedical, industrial, and agricultural fields.
El-Sayyad is a member of the Nanotechnology Research Unit, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt. His research papers under the project “Nutraceuticals and Functional Foods Production by using Nano/ Biotechnological and Irradiation Processes”.
El-Sayyad received the State Encouragement Award in Basic Biological Sciences for the year 2020 and his name is included in the list of the 2% of the most distinguished and influential scientists in the world according to the classification of the international publishing house Elsevier and Scopas with Stanford University of America for the year 2020.